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Personalized Medicine: Real Opportunities And Real Challenges For Doctors

Greg McStravick

In the first of a three-part series on how technology is transforming healthcare, Greg McStravick, GM and global head, SAP Platform GTM, takes a look at the potential of personalized medicine. Technology has the potential to create real value, but short-term challenges are significant. Find out more about technology and healthcare challenges and opportunities in Parts 2 and 3:

  • Part 2: Personalized Medicine and Big Data–Opportunities and Pitfalls of IT Innovation
  • Part 3: The Risks, Challenges–and Rewards–of Ensuring Medical Data Privacy

As we observe National Heart Month (#NationalHeartMonth) this February, it is both encouraging and exciting that a new effort is underway to create tailor-made medicine and medical treatments by drawing on exceptionally detailed and extensive biomedical data. The effort is ambitious and challengingand possible. The goal: wide availability of personalized medical care (aka precision medicine) that can be customized based on an individual’s genetic makeup and other factors.

But collecting this level of personal health care information, while it holds the possibility of game-changing personalized drugs and treatments, is not without major challenges–including those in the realms of patient privacy and data storage. Highly individualized diagnosis and treatment available on a large scale requires collection and management of petabytes of data, including but not limited to patient histories, genetic data, data from wearable health monitors, and information on individual microbiomes (bacteria, fungi, and viruses in and on the body). Privacy is of utmost concern, and even current big data standards could be strained by massive amounts of genetic data.

The possibilities are compelling, and the upside is huge. But personalized medicine is a challenge with real, difficult, and perhaps intractable problems attached.

Are we there yet?

We’ve been able to sequence the human genome for about 15 years. In certain specialties, such as oncology, we’re already seeing tremendous advancements thanks to genometrics. Cancer used to be thought of in terms of a cell gone wrong that affected the tissue around it, with treatments based on affected area – for example, lung, breast, or skin. Now, researchers are looking to treat each mutation by responding to its genetic fingerprint. The same treatment might be applicable regardless of the organ or tissue affected, and, for example, one patient’s lung cancer treatment might differ from another’s due to genetic differences in each person’s mutation.

However, along with important breakthroughs and new therapies to treat formerly untreatable diseases, we’ve also seen the need for exponentially more complex understanding – from not just researchers but front-line doctors. Now that we can sequence the DNA, we must understand and transcribe epigenomes, proteomes, metabolomes, and more. This poses a huge challenge for on-the-ground medical personnel, including primary care providers and specialists whose focus is broadly defined quality care.

Friend or foe?

The majority of physicians believe that personalized medicine will eventually create real value for individuals as well as entire populations. But in the short term, what will the average family practitioner get for her efforts? Physicians are under stress, working more and seeing patients less. Many doctors have just completed mandatory transitions to electronic medical records (EMRs), which has required more work but yielded little in tangible results. Privacy laws, insurance paperwork, and the shift to value-based pricing are requiring more data input and creating more hoops to jump through, lengthening the workday but providing minimal tangible value for patients and doctors. The fear here is that personalized medicine could mean more of the same for the vast majority of providers. Would primary care doctors need to verify even more information when a person is sick, taking into account all the additional characteristics that drive a doctor toward different therapies? Will all the new inputs yield equivalent benefits?

Outside the office

I believe that in order for personalized medicine to take off, we’ll need to capture not just genomic information, but accurate information about individual patients that falls well outside current hospital or clinical settings. How do patients live in their homes? What do they eat, drink, and smoke? What’s their documented level of physical and social activity? And even more important, how do we engage patients, especially those with chronic illness, in ways that support real change of unhealthy habits? I believe that for personalized medicine to reach its full preventative potential, the medical profession will have to engage with patients in their homes.

Also, correlating such lifestyle data is critically important to understanding and applying genomic data when predicting risk factors for certain diseases. But how will this lifestyle data be captured and stored? What infrastructure will be needed, and how will it be funded? Before we can consistently, accurately, and cost-effectively collect this data, we need a technology infrastructure and payment model in place.

Best practices: A final challenge

It can be a major challenge for the medical profession to implement best practices. Even when best practices are proven in controlled, randomized trials, it has often taken up to 20 years for a practice to be consistently adopted. Given this challenge, for personalized medicine protocols to really work for–and be consistently adopted by–doctors, they must:

  • Be time-neutral
  • Integrate into current workflows
  • Drive clear value for both doctors and their patients

It’s only when we address all these challenges–both technological and human-based–that we will be able to truly take advantage of the benefits that personalized medicine can offer.

Learn more about the SAP Foundation for Health and Personalized Medicine

SAP is passionate about creating transformative technology that can advance healthcare. The SAP Foundation for Health includes a sophisticated platform and advanced analytic solutions that can help unlock the value of biomedical data–from genomes to electronic medical records to clinical trials. Supporting deeper insights and enabling collaboration, the SAP Foundation for Health helps connect data silos and bring together mission-critical biomedical data, advancing personalized medicine to new levels.

Visit SAP at #HIMSS16 Booth #5828 February 29-March 4 to learn more, or continue the discussion on Twitter @SAP_Healthcare.

 

 

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Greg McStravick

About Greg McStravick

Greg McStravick is the President of Database and Data Management at SAP, leading development and go-to-market teams for SAP’s core digital innovation platform, SAP HANA and Sybase databases (including ASE, and IQ), enterprise information management, middleware, and SAP HANA Vora. Formerly, Greg led the go-to-market teams and strategy for some of SAP’s largest and fastest growing businesses including the SAP HANA platform, analytics, database, and SAP HANA Cloud Platform. With more than 20 years of progressive experience as a leader in technology solution sales management and strategy, Greg has held senior leadership positions throughout SAP, including President (U.S.), where he was responsible for driving customer success and developing new opportunities for SAP to expand its business across the entire U.S. region.

IoT Can Keep You Healthy — Even When You Sleep [VIDEO]

Christine Donato

Today the Internet of Things is revamping technology. IoT image from American Geniuses.jpg

Smart devices speak to each other and work together to provide the end user with a better product experience.

Coinciding with this change in technology is a change in people. We’ve transitioned from a world of people who love processed foods and french fries to people who eat kale chips and Greek yogurt…and actually like it.

People are taking ownership of their well-being, and preventative care is at the forefront of focus for both physicians and patients. Fitness trackers alert wearers of the exact number of calories burned from walking a certain number of steps. Mobile apps calculate our perfect nutritional balance. And even while we sleep, people are realizing that it’s important to monitor vitals.

According to research conducted at Harvard University, proper sleep patterns bolster healthy side effects such as improved immune function, a faster metabolism, preserved memory, and reduced stress and depression.

Conversely, the Harvard study determined that lack of sleep can negatively affect judgement, mood, and the ability retain information, as well as increase the risk of obesity, diabetes, cardiovascular disease, and even premature death.

Through the Internet of Things, researchers can now explore sleep patterns without the usual sleep labs and movement-restricting electrode wires. And with connected devices, individuals can now easily monitor and positively influence their own health.

EarlySense, a startup credited with the creation of continuous patient monitoring solutions focused on early detection of patient deterioration, mid-sleep falls, and pressure ulcers, began with a mission to prevent premature and preventable deaths.

Without constant monitoring, patients with unexpected clinical deterioration may be accidentally neglected, and their conditions can easily escalate into emergency situations.

Motivated by many instances of patients who died from preventable post-elective surgery complications, EarlySense founders created a product that constantly monitors patients when hospital nurses can’t, alerting the main nurse station when a patient leaves his or her bed and could potentially fall, or when a patient’s vital signs drop or rise unexpectedly.

Now EarlySense technology has expanded outside of the hospital realm. The EarlySense wellness sensor, a device connected via the Internet of Things, mobile solutions, and supported by SAP HANA Cloud Platform, monitors all vital signs while a person sleeps. The device is completely wireless and lies subtly underneath one’s mattress. The sensor collects all mechanical vibrations that the patient’s body emits while sleeping, continuously monitoring heart and respiratory rates.

Watch this short video to learn more about how the EarlySense wellness sensor works:

The result is faster diagnoses with better treatments and outcomes. Sleep issues can be identified and addressed; individuals can use the data collected to make adjustments in diet or exercise habits; and those on heavy pain medications can monitor the way their bodies react to the medication. In addition, physicians can use the data collected from the sensor to identify patient health problems before they escalate into an emergency situation.

Connected care is opening the door for a new way to practice health. Through connected care apps that link people with their doctors, fitness trackers that measure daily activity, and sensors like the EarlySense wellness sensor, today’s technology enables people and physicians to work together to prevent sickness and accidents before they occur. Technology is forever changing the way we live, and in turn we are living longer, healthier lives.

To learn how SAP HANA Cloud Platform can affect your business, visit It&Me.

For more stories, join me on Twitter.

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Christine Donato

About Christine Donato

Christine Donato is a Senior Integrated Marketing Specialist at SAP. She is an accomplished project manager and leader of multiple marketing and sales enablement campaigns and events, that supported a multi million euro business.

Zhena’s Gypsy Tea Brews Sustainable Growth On Cloud ERP

David Trites

Recently I had the pleasure of hosting a podcast with Paula Muesse, COO and CFO of Zhena’s Gypsy Tea, a small, organic, fair-trade tea company based in California, and Ursula Ringham from SAP. We talked about some of the business challenges Zhena’s faces and how the company’s ERP solution helped spur growth and digital transformation.

Small but complex business

~ERP helped Zhena’s sustain growthZhena’s has grown from one person (Zhena Muzyka) selling hand-packed tea from a cart, into a thriving small business that puts quality, sustainability, and fair trade first. And although the company is small its business is complex.

For starters, tea isn’t grown in the United States, so Zhena’s has to maintain and import inventory from multiple warehouses around the world. Some of their tea blends have up to 14 ingredients, and each one has a different lead time. That makes demand-planning difficult. In addition, the FDA and US Customs require designated ingredients be traced and treated a certain way to comply with regulations.

Being organic and fair trade also makes things more complicated. Zhena’s has to pass an annual organic compliance audit for all products and processing facilities. And all products need to be traceable back to the farms where the tea was grown and picked to ensure the workers (mostly women) are paid fair wages.

Sustainable growth

Prior to implementing its new ERP system, Zhena’s was using a mix of tools like QuickBooks, Excel, and paper to manage the business. But to sustain growth and ensure future success, the company had to make some changes. Zhena’s needed an integrated software solution that could handle all facets of the business. It needed a tool that could help with cost control and profitability analysis and facilitate complex reporting and regulatory requirements.

The SAP Business ByDesign solution was the perfect choice. The cloud-based ERP solution reduced both business and IT costs, simplified processes from demand planning to accounting, and enabled mobile access and real-time reporting.

Check out the podcast to hear more about how Zhena’s successfully transformed its business by moving to SAP Business ByDesign.

 This article originally appeared on SAP Business Trends.

Building a successful company is hard work. SAP’s affordable solutions for small and midsize companies are designed to make it easier. Simple to install and use, SAP SME Solutions help you automate and integrate your business processes to give real-time, actionable insights. So you can make decisions on the spot. Find out how Run Simple can work for you. Visit sap.com/sme.

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David Trites

About David Trites

David Trites is a Director of SAP Global Marketing. He is responsible for producing interesting and compelling customer stories that will humanize the SAP brand, support sales and marketing teams across SAP, and increase the awareness of SAP in key markets.

The Future of Cybersecurity: Trust as Competitive Advantage

Justin Somaini and Dan Wellers

 

The cost of data breaches will reach US$2.1 trillion globally by 2019—nearly four times the cost in 2015.

Cyberattacks could cost up to $90 trillion in net global economic benefits by 2030 if cybersecurity doesn’t keep pace with growing threat levels.

Cyber insurance premiums could increase tenfold to $20 billion annually by 2025.

Cyberattacks are one of the top 10 global risks of highest concern for the next decade.


Companies are collaborating with a wider network of partners, embracing distributed systems, and meeting new demands for 24/7 operations.

But the bad guys are sharing intelligence, harnessing emerging technologies, and working round the clock as well—and companies are giving them plenty of weaknesses to exploit.

  • 33% of companies today are prepared to prevent a worst-case attack.
  • 25% treat cyber risk as a significant corporate risk.
  • 80% fail to assess their customers and suppliers for cyber risk.

The ROI of Zero Trust

Perimeter security will not be enough. As interconnectivity increases so will the adoption of zero-trust networks, which place controls around data assets and increases visibility into how they are used across the digital ecosystem.


A Layered Approach

Companies that embrace trust as a competitive advantage will build robust security on three core tenets:

  • Prevention: Evolving defensive strategies from security policies and educational approaches to access controls
  • Detection: Deploying effective systems for the timely detection and notification of intrusions
  • Reaction: Implementing incident response plans similar to those for other disaster recovery scenarios

They’ll build security into their digital ecosystems at three levels:

  1. Secure products. Security in all applications to protect data and transactions
  2. Secure operations. Hardened systems, patch management, security monitoring, end-to-end incident handling, and a comprehensive cloud-operations security framework
  3. Secure companies. A security-aware workforce, end-to-end physical security, and a thorough business continuity framework

Against Digital Armageddon

Experts warn that the worst-case scenario is a state of perpetual cybercrime and cyber warfare, vulnerable critical infrastructure, and trillions of dollars in losses. A collaborative approach will be critical to combatting this persistent global threat with implications not just for corporate and personal data but also strategy, supply chains, products, and physical operations.


Download the executive brief The Future of Cybersecurity: Trust as Competitive Advantage.


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How Digital Transformation Is Rewriting Business Models

Ginger Shimp

Everybody knows someone who has a stack of 3½-inch floppies in a desk drawer “just in case we may need them someday.” While that might be amusing, the truth is that relatively few people are confident that they’re making satisfactory progress on their digital journey. The boundaries between the digital and physical worlds continue to blur — with profound implications for the way we do business. Virtually every industry and every enterprise feels the effects of this ongoing digital transformation, whether from its own initiative or due to pressure from competitors.

What is digital transformation? It’s the wholesale reimagining and reinvention of how businesses operate, enabled by today’s advanced technology. Businesses have always changed with the times, but the confluence of technologies such as mobile, cloud, social, and Big Data analytics has accelerated the pace at which today’s businesses are evolving — and the degree to which they transform the way they innovate, operate, and serve customers.

The process of digital transformation began decades ago. Think back to how word processing fundamentally changed the way we write, or how email transformed the way we communicate. However, the scale of transformation currently underway is drastically more significant, with dramatically higher stakes. For some businesses, digital transformation is a disruptive force that leaves them playing catch-up. For others, it opens to door to unparalleled opportunities.

Upending traditional business models

To understand how the businesses that embrace digital transformation can ultimately benefit, it helps to look at the changes in business models currently in process.

Some of the more prominent examples include:

  • A focus on outcome-based models — Open the door to business value to customers as determined by the outcome or impact on the customer’s business.
  • Expansion into new industries and markets — Extend the business’ reach virtually anywhere — beyond strictly defined customer demographics, physical locations, and traditional market segments.
  • Pervasive digitization of products and services — Accelerate the way products and services are conceived, designed, and delivered with no barriers between customers and the businesses that serve them.
  • Ecosystem competition — Create a more compelling value proposition in new markets through connections with other companies to enhance the value available to the customer.
  • Access a shared economy — Realize more value from underutilized sources by extending access to other business entities and customers — with the ability to access the resources of others.
  • Realize value from digital platforms — Monetize the inherent, previously untapped value of customer relationships to improve customer experiences, collaborate more effectively with partners, and drive ongoing innovation in products and services,

In other words, the time-tested assumptions about how to identify customers, develop and market products and services, and manage organizations may no longer apply. Every aspect of business operations — from forecasting demand to sourcing materials to recruiting and training staff to balancing the books — is subject to this wave of reinvention.

The question is not if, but when

These new models aren’t predictions of what could happen. They’re already realities for innovative, fast-moving companies across the globe. In this environment, playing the role of late adopter can put a business at a serious disadvantage. Ready or not, digital transformation is coming — and it’s coming fast.

Is your company ready for this sea of change in business models? At SAP, we’ve helped thousands of organizations embrace digital transformation — and turn the threat of disruption into new opportunities for innovation and growth. We’d relish the opportunity to do the same for you. Our Digital Readiness Assessment can help you see where you are in the journey and map out the next steps you’ll need to take.

Up next I’ll discuss the impact of digital transformation on processes and work. Until then, you can read more on how digital transformation is impacting your industry.

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Ginger Shimp

About Ginger Shimp

With more than 20 years’ experience in marketing, Ginger Shimp has been with SAP since 2004. She has won numerous awards and honors at SAP, including being designated “Top Talent” for two consecutive years. Not only is she a Professional Certified Marketer with the American Marketing Association, but she's also earned her Connoisseur's Certificate in California Reds from the Chicago Wine School. She holds a bachelor's degree in journalism from the University of San Francisco, and an MBA in marketing and managerial economics from the Kellogg Graduate School of Management at Northwestern University. Personally, Ginger is the proud mother of a precocious son and happy wife of one of YouTube's 10 EDU Gurus, Ed Shimp.